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Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid GABA that was first approved for use in the United States in It is structurally and functionally related to another GABA derivative, pregabalin. In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.
It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy. Gabapentin Gabapentin drug type an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders.
Gabapentin is ineffective in absence seizures and should be used in caution in patients with mixed seizure disorders involving absence seizures. Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms DRESSotherwise known as multi-organ hypersensitivity. This reaction can prove fatal and early symptoms such as fever, lymphadenopathy, and rash should be Gabapentin drug type investigated. The precise mechanism through which gabapentin exerts its therapeutic effects is unclear.
There is some evidence that gabapentin also acts on adenosine receptors 1512 and voltage-gated potassium channels, 13 though the clinical relevance of its action at these sites is unclear. Absorption of gabapentin is thought to occur solely via facilitated transport by the LAT1 transporter within the intestines.
Gabapentin is eliminated solely in the urine as unchanged drug. Both the plasma clearance and renal clearance of gabapentin are directly proportional to the patient's creatinine clearance due to its primarily renal elimination. The oral TDLo of gabapentin in humans is 2. Gabapentin can be removed by hemodialysis - this may be of benefit in some patients, such as those with impaired renal function.
Multi-drug overdoses involving gabapentin, particularly in combination with other CNS depressants such as opioids, can result in coma and death - this possibility should be considered when managing overdosage. Donald E. Butler, Barbara J. Greenman, "Gabapentin mohohydrate and a process for producing the same. Patent US, issued May, Gabapentin drug type Drug Interactions Food Interactions. Clinical Trials. Spectra Mass Spec Spectra. Targets 6. Enzymes 1. Transporters 1.
Identification Summary Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Brand Names Gralise, Neurontin. With our commercial data, access important information on dangerous risks, contraindications, and adverse effects. Learn more. This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately.
The absence of an interaction does not necessarily mean no interactions exist. Drug Interaction Integrate drug-drug interactions in your software. Improve patient outcomes. From application s to product codesconnect different identifiers through our commercial datasets. Actavis elizabeth llc Amneal pharmaceuticals ny llc Apotex inc etobicoke site Aurobindo pharma usa inc Hikma pharmaceuticals Invagen pharmaceuticals inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Mutual pharmaceutical co inc Ranbaxy laboratories ltd Sandoz inc Sun pharmaceutical industries ltd Teva pharmaceuticals usa Watson laboratories inc Pfizer pharmaceuticals ltd Parke davis div warner lambert co Glenmark generics ltd Matrix laboratories ltd Teva pharmaceuticals usa inc.
Amneal Pharmaceuticals Apotex Inc. Apotheca Inc. Golden State Medical Supply Inc. Greenstone LLC H. Harkins Co. Major Pharmaceuticals Mckesson Corp. Medvantx Inc. Palmetto Pharmaceuticals Inc. Pfizer Inc. Preferred Pharmaceuticals Inc. Prepak Systems Inc.
Professional Co. Ranbaxy Laboratories Rebel Distributors Corp. Teva Pharmaceutical Industries Ltd. Vangard Labs Inc. DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Targets Accelerate your drug discovery research. Plays an important role in excitation Semin Cell Dev Biol. Epub Sep Epub Feb Arch Pharm Res. General Function Voltage-sensitive calcium channels VSCC mediate the entry of calcium ions into Gabapentin drug type cells and are also involved Gabapentin drug type a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
The isoform alpha-1B gives rise to N-type calcium currents. Specific Function Voltage-gated calcium channel activity. Anesth Analg. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Zuchora B, Wielosz M, Urbanska EM: Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice. Eur Neuropsychopharmacol. J Peripher Nerv Syst. General Gabapentin drug type Voltage-gated potassium channel activity Specific Function Probably important in the regulation of neuronal excitability.
Mol Pharmacol. Epub Jul Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium General Function L-valine transaminase activity Specific Function Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. J Biol Chem. Epub Sep 1. Involved in cellular a Biochem Pharmacol.
Epub Apr 6. Clin Pharmacokinet. Show full image. U Voltage-dependent N-type calcium channel. U Adenosine receptor A1. U Potassium voltage-gated channel subfamily KQT member 3. U Potassium voltage-gated channel subfamily KQT member 5.
The risk or severity of adverse effects can be increased when Gabapentin is combined with 1,2-Benzodiazepine. The risk or severity of adverse effects can be increased when Acetazolamide is combined with Gabapentin.Gabapentin drug type
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